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A t(9;11) translocation in childhood acute mixed leukemia
M L Chauffaille1, M Yamamoto, V Odone Filho
1Department of Hematology, Escola Paulista de Medicina, São Paulo, Brazil.
Sao Paulo Medical Journal = Revista Paulista De Medicina
|March 1, 1996
Abstract:
We present the case of a child with acute lymphoid leukemia (ALL) who was morphologically classified as FAB L1 (PAS and peroxidase were negative). Remission was achieved with an ALL-type protocol (GBTLI). Five months after the discontinuation of therapy, the patient presented mixed leukemia (CD10, CD19, CD13 and CD33 were positive) with t (9;11) (p21;q23) translocation. Unfortunately, as cytogenetic and immunophenotype studies were not performed at diagnosis, two possibilities could be considered for the relapse; secondary mixed leukemia with clonal chromosome changes, or mixed leukemia from the beginning.