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Tolerance: a case of self/not-self discrimination maintained by clonal deletion?

K J Lafferty1, L S Gazda

  • 1Division of Molecular Medicine, John Curtin School of Medical Research, Australian National University, Canberra.

Human Immunology
|February 1, 1997
PubMed
Summary

The clonal selection theory faces challenges with modern antigen presentation. Matzinger's "danger" model offers a new path for controlling autoimmunity through enhanced immune regulation with adjuvant therapy.

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