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Related Experiment Videos

Preterm and small-for-gestational-age birth across generations

M A Klebanoff1, C Schulsinger, B R Mednick

  • 1Epidemiology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-7510, USA.

American Journal of Obstetrics and Gynecology
|March 1, 1997
PubMed
Summary

Maternal small for gestational age (SGA) birth increases the risk of having an SGA child. However, maternal preterm birth is not strongly linked to preterm delivery in offspring.

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Area of Science:

  • Reproductive Health
  • Perinatal Epidemiology
  • Developmental Origins of Health and Disease (DOHaD)

Background:

  • The intergenerational transmission of growth and timing of birth is a key area in reproductive health.
  • Understanding these risks can inform prenatal care and interventions.

Purpose of the Study:

  • To investigate if women born small for gestational age (SGA) are at higher risk of delivering SGA infants.
  • To determine if women born preterm are at higher risk of preterm delivery.

Main Methods:

  • Utilized data from the Danish Perinatal Study (1959-1961) for women born in Copenhagen.
  • Traced participants through the Danish Population Register to gather pregnancy data from 1974-1989.

Main Results:

Related Experiment Videos

  • Children of mothers born SGA were more likely to be SGA (25% vs. 11%).
  • Mothers born preterm had a slightly higher rate of preterm delivery (11% vs. 7%).
  • Adjusted odds ratios indicated a significant association between maternal SGA status and offspring SGA, but not for preterm birth.

Conclusions:

  • Maternal small for gestational age is a risk factor for reduced intrauterine growth in offspring.
  • Maternal preterm birth does not appear to be a strong risk factor for preterm delivery in subsequent pregnancies.