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Methotrexate pneumonitis after systemic treatment for ectopic pregnancy
T J Horrigan1, J Fanning, M P Marcotte
1Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008, USA.
Abstract:
Pneumonitis is an infrequent complication of methotrexate therapy. Described is a case of pneumonitis after treatment of an ectopic pregnancy. A 20-year-old white woman, gravida 3, para 0, ectopic pregnancy 2, was treated for her third ectopic pregnancy with 88 mg (50 mg/m2) of intramuscular methotrexate. Four days later acute dyspnea, tachypnea, fever, patchy infiltrates on chest x-ray films, and a PO2 of 30 mm Hg developed. Respiratory distress resolved over 48 hours. Pneumonitis should be suspected in any patient treated with methotrexate who has unexplained dyspnea.
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