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Recurrent Crohn's disease in transplanted bowel
N Sustento-Reodica1, P Ruiz, A Rogers
1Department of Pathology, Jackson Memorial Hospital, Miami, Florida, USA.
Lancet (London, England)
|March 8, 1997
Summary
Crohn
Area of Science:
- Gastroenterology
- Transplantation Immunology
Background:
- Intestinal transplantation is a treatment for short-bowel syndrome in Crohn's disease patients.
- Recurrence of Crohn's disease post-transplant is a significant concern.
Observation:
- A patient developed recurrent Crohn's disease symptoms within six months of intestinal transplantation.
- Histopathological analysis confirmed Crohn's disease in the transplanted intestine.
Findings:
- Crohn's disease recurred rapidly in a transplanted small bowel.
- The recurrence occurred despite potent immunosuppressive therapy.
Implications:
- This case offers insights into the autoimmune nature of Crohn's disease.
- Understanding recurrence mechanisms is crucial for post-transplant management.