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Related Experiment Videos

Penicillin--intermediate-resistant pneumococcal spondylodiscitis

J A Arranz-Caso1, N Solé, A Sanchez-Atrio

  • 1Internal Medicine, Rehumatology, Department Príncipe de Asturias University Hospital, School of Medicine, University of Alcalá de Henares, Madrid, Spain.

Diagnostic Microbiology and Infectious Disease
|November 1, 1996
PubMed
Summary
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Pneumococcal osteomyelitis is rare but can be caused by penicillin-resistant Streptococcus pneumoniae. This case highlights primary bacteremia as a potential infection source, especially in vulnerable patients.

Area of Science:

  • Infectious Diseases
  • Orthopedics
  • Microbiology

Background:

  • Pneumococcal osteomyelitis, though rare today, was more common pre-antibiotics.
  • Predisposing factors include sickle-cell disease, bone trauma, and advanced age.
  • Infection typically arises from hematogenous spread, often from an unidentified focus.

Observation:

  • Pneumococcal spondylodiscitis without other infection foci suggests primary bacteremia from the oropharynx.
  • Altered oropharyngeal mucosa may facilitate primary pneumococcal bacteremia.
  • A case of vertebral and intervertebral disk disease caused by penicillin-resistant Streptococcus pneumoniae is presented.

Findings:

  • Streptococcus pneumoniae is increasingly resistant to penicillin, posing a significant global challenge.

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  • The presented case involved a young patient with vertebral and disk disease due to penicillin-resistant pneumococci.
  • No concurrent pneumococcal infection was identified in the patient.

    • Implications:

    • Understanding primary bacteremia is crucial for diagnosing and treating rare pneumococcal bone infections.
    • The rise in penicillin resistance necessitates alternative treatment strategies for Streptococcus pneumoniae infections.
    • This case underscores the importance of considering antibiotic resistance in clinical decision-making for osteomyelitis.