Related Experiment Videos
Clinical uses of antiprogestogens
1Special Programme of Research, Development and Research Training in Human Reproduction, World Health Organization, Geneva, Switzerland.
Human Reproduction Update
|January 1, 1995
Summary
Antiprogestogens, like mifepristone, are significant endocrinology developments. They block progesterone and have gynecological, fertility, and antiglucocorticoid applications, though dual activity is a concern.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Antiprogestogens block progesterone receptor action.
- Mifepristone, lilopristone, and onapristone are key compounds.
- Research focuses on mifepristone's applications.
Purpose of the Study:
- To review antiprogestogen development and applications.
- To explore clinical uses in gynecology, obstetrics, and fertility.
- To discuss antiglucocorticoid effects and potential therapeutic uses.
Main Methods:
- Literature review of antiprogestogen research.
- Analysis of clinical data for mifepristone and related compounds.
- Evaluation of biological screening models and human trials.
Main Results:
- Mifepristone is used for pregnancy termination, cervical ripening, and labor induction.
- Antiprogestogens show efficacy in fertility regulation (contraception, menses induction).
- Mifepristone's antiglucocorticoid activity aids Cushing's syndrome treatment.
Conclusions:
- Antiprogestogens have diverse gynecological and fertility applications.
- Dual antiprogestational and antiglucocorticoid activity presents therapeutic opportunities and challenges.
- Development of selective antiprogestogens or antiglucocorticoids is desirable.