Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Prefrontal cortex fMRI signal changes are correlated with working memory load

D S Manoach1, G Schlaug, B Siewert

  • 1Behavioral Neurology Unit, Beth Israel Hospital, Harvard Medical School, Boston, MA 02215, USA.

Neuroreport
|January 20, 1997
PubMed
Summary

This study shows that the dorsolateral prefrontal cortex (DLPFC) and intraparietal sulcus (IPS) are activated during nonspatial working memory (WM) tasks. DLPFC activation levels correlate with the working memory load.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MIR137 polygenic risk for schizophrenia and ephrin-regulated pathway: Role in lateral ventricles and corpus callosum volume.

International journal of clinical and health psychology : IJCHP·2024
Same author

Diazepam induced sleep spindle increase correlates with cognitive recovery in a child with epileptic encephalopathy.

BMC neurology·2021
Same author

Comparison of technical success and safety of transbronchial versus percutaneous CT-guided fiducial placement for SBRT of lung tumors.

Journal of medical imaging and radiation sciences·2021
Same author

Non-Contrast-Enhanced Carotid MRA: Clinical Evaluation of a Novel Ungated Radial Quiescent-Interval Slice-Selective MRA at 1.5T.

AJNR. American journal of neuroradiology·2019
Same author

Predicting Motor Outcome in Acute Intracerebral Hemorrhage.

AJNR. American journal of neuroradiology·2019
Same author

Green light-induced apoptosis in cancer cells by a tetrapyridyl ruthenium prodrug offering two <i>trans</i> coordination sites.

Chemical science·2018

Area of Science:

  • Cognitive Neuroscience
  • Neuroimaging
  • Human Brain Function

Background:

  • Working memory (WM) is crucial for cognitive tasks.
  • The role of specific brain regions like the dorsolateral prefrontal cortex (DLPFC) in nonspatial WM requires further investigation.
  • Understanding brain activation patterns related to WM load is essential for cognitive neuroscience.

Purpose of the Study:

  • To determine if a nonspatial working memory (WM) task activates the dorsolateral prefrontal cortex (DLPFC).
  • To examine the correlation between DLPFC activation and working memory load.
  • To identify other brain regions involved in nonspatial WM.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to measure brain signal changes.

Related Experiment Videos

  • Twelve healthy subjects performed a continuous performance, choice reaction time task.
  • Comparisons included a high WM load versus a non-WM control and a low WM load condition.

    • Main Results:

    • Significant signal changes were observed in the DLPFC, frontal motor regions, and the intraparietal sulcus (IPS).
    • Activation in the DLPFC and IPS was evident in both WM load comparisons.
    • DLPFC signal changes demonstrated a correlation with the working memory load.

    Conclusions:

    • The findings support the involvement of the DLPFC and IPS in working memory.
    • DLPFC activation intensity is associated with the demands of the working memory task.
    • This study elucidates the neural correlates of nonspatial working memory and its load-dependent nature.