Related Experiment Videos
Comparison of uptake of 99mTc-alkylisonitriles in the rat 9L gliosarcoma tumor model
A B Packard1, E Barbarics, J F Kronauge
1Division of Nuclear Medicine, Children's Hospital, Boston, MA 02115, USA.
Nuclear Medicine and Biology
|January 1, 1997
Abstract:
The accumulation of three 99mTc(I) alkyl isonitriles was compared in vitro and in vivo using 9L gliosarcoma cells. In vitro, the uptake of 99mTc-EIBI and 99mTc-EPI was higher than that of 99mTc-MIBI. In vivo, however, there was no difference in the tumor concentration at 15 or 60 min postinjection and only a small difference at 24 h. The differences in uptake observed in vitro are apparently offset in vivo by differences in delivery of the tracers to the tumor.