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DNA gyrase as a drug target
1Dept of Biochemistry, University of Leicester, UK. ony@leicester.ac.uk
Trends in Microbiology
|March 1, 1997
Abstract:
DNA gyrase is a remarkable enzyme, catalysing the seemingly complex reaction of DNA supercoiling. As gyrase is essential in prokaryotes, it is a good target for antibacterial agents. These agents have diverse chemical structures and interact with gyrase in a variety of ways.