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Related Experiment Videos

Evolution and development--the nematode vulva as a case study

R J Sommer1

  • 1Max-Planck Institut für Entwicklungsbiologie, Abt. Zellbiologie, Tübingen, Germany. sora@fserv1.mpib-tuebingen.mpg.de

Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology
|March 1, 1997
PubMed
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Hybrid crosses and the genetic basis of interspecific divergence in lifespan in Pristionchus nematodes.

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An integrated physical and genetic map of the nematode Pristionchus pacificus.

Molecular genetics and genomics : MGG·2003
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As good as they get: cells in nematode vulva development and evolution.

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Formation of the egg-laying system in Pristionchus pacificus requires complex interactions between gonadal, mesodermal and epidermal tissues and does not rely on single cell inductions.

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Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.

Genes & development·2001
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Microevolutionary analysis of the nematode genus Pristionchus suggests a recent evolution of redundant developmental mechanisms during vulva formation.

Evolution & development·2001

Evolutionary developmental biology uses nematodes to study how cell fate specification changes over time. Researchers compare species like Pristionchus pacificus to model organisms to find genetic causes of evolutionary alterations.

Area of Science:

  • Evolutionary developmental biology
  • Comparative genomics
  • Cellular biology

Background:

  • Understanding morphological evolution requires insight into developmental processes.
  • Comparative developmental studies are crucial for various animal and plant systems.
  • Nematodes offer a powerful model for investigating genetic and molecular bases of evolutionary changes in development.

Purpose of the Study:

  • To explore evolutionary alterations in cell fate specification using nematodes.
  • To identify genetic and molecular mechanisms driving developmental evolution.
  • To analyze changes in cell lineage, migration, and death during evolution.

Main Methods:

  • Comparative analysis of vulva development across different nematode species.

Related Experiment Videos

  • Utilizing Caenorhabditis elegans as a genetic model system for comparison.
  • Employing genetic approaches in Pristionchus pacificus to identify causative genes.

    • Main Results:

    • Observed evolutionary alterations include changes in cell lineage, cell migration, and cell death.
    • Variations in induction and cell competence were identified.
    • A genetic approach in P. pacificus is being developed to pinpoint genetic drivers of evolutionary change.

    Conclusions:

    • Nematodes provide a valuable system for studying the genetic underpinnings of evolutionary developmental changes.
    • Comparative analysis of cell fate specification reveals key evolutionary alterations.
    • Future genetic studies in P. pacificus aim to elucidate molecular mechanisms of developmental evolution.