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Related Experiment Videos

Syncope after immunization

M M Braun1, P A Patriarca, S S Ellenberg

  • 1Center for Biologics Evaluation and Research, Food and Drug Administration, Rockville, Md, USA.

Archives of Pediatrics & Adolescent Medicine
|March 1, 1997
PubMed
Summary
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Syncope after immunization is common, especially in young females, often occurring within 30 minutes. Careful observation post-vaccination can prevent injuries from fainting.

Area of Science:

  • Immunology
  • Neurology
  • Public Health

Background:

  • Syncope, or fainting, can occur after immunization.
  • Understanding its characteristics and associated injuries is crucial for patient safety.

Purpose of the Study:

  • To detail the characteristics, clinical presentation, and morbidity of syncope following immunization.
  • To identify risk factors and timing of post-vaccination syncope.

Main Methods:

  • A large case series analysis of syncope reports in the United States from 1990-1995.
  • Data sourced from the Vaccine Adverse Event Reporting System (VAERS) and National Vaccine Injury Compensation Program.

Main Results:

  • 697 cases of syncope post-vaccination were reported, predominantly in individuals under 20 (77.4%) and females (57.5%).

Related Experiment Videos

  • Most syncope events (97.8%) occurred within 30 minutes of vaccination, with 63.2% within 5 minutes.
  • Injuries, including skull fractures, occurred in 6 patients following falls within 15 minutes post-vaccination.

    • Conclusions:

    • Syncope and associated injuries after immunization are preventable in many cases.
    • Healthcare providers should monitor patients for presyncopal symptoms and assist them to sit or lie down post-vaccination.