Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Acute intensive interval training and in vitro t-lymphocyte function

J R Hinton1, D G Rowbottom, D Keast

  • 1Department of Biomedical Science, Anglia Polytechnic University, Cambridge, United Kingdom.

International Journal of Sports Medicine
|February 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical Activity and the Asthmatic.

The Physician and sportsmedicine·2016
Same author

Beta-Blockade and Response to Exercise: Influence of Training.

The Physician and sportsmedicine·2016
Same author

Ethanol-induced osmolality changes and lymphocyte proliferation.

Addiction biology·2016
Same author

Studies on the ecology of West Australian actinomycetes: Factors which influence the diversity and types of actionomycetes in Australian soils.

Microbial ecology·2013
Same author

Distribution of glutamine synthetase in the snapper (Pagrus auratus) and implications for the immune system.

Fish physiology and biochemistry·2013
Same author

Osmotic effects of ethanol on lymphocytes.

Addiction biology·2010
Same journal

Leukocyte Morphology Changes during Preseason in Elite Soccer Players: A Pilot Study.

International journal of sports medicine·2026
Same journal

Improving assessment of post-exercise hypotension as a predictor of training efficacy.

International journal of sports medicine·2026
Same journal

Neuromuscular electrical stimulation after anterior cruciate ligament reconstruction.

International journal of sports medicine·2026
Same journal

Exercise Intensity Effects on Irisin in Master Athletes and Links With Maximal Oxygen Uptake and Body Fat.

International journal of sports medicine·2026
Same journal

Evolution of the Australian Institute of Sport Supplement Program over the last 25 years.

International journal of sports medicine·2026
Same journal

Preseason Passive Torque Asymmetries in Soccer Players with Hamstring Strain Injury.

International journal of sports medicine·2026
See all related articles

Intensive exercise temporarily reduced total lymphocyte function, but not T-lymphocytes. Increased natural killer (NK) cells, not T-cells, likely caused this temporary immune response change.

Area of Science:

  • Exercise Immunology
  • Cellular Immunology
  • Sports Science

Background:

  • Intensive exercise can transiently alter immune function.
  • Understanding lymphocyte subset responses to high-intensity training is crucial.

Purpose of the Study:

  • To investigate the impact of intensive interval running on lymphocyte function and composition.
  • To differentiate the response of total lymphocytes versus pure T-lymphocyte subsets.

Main Methods:

  • Endurance-trained runners performed high-intensity interval running (15 x 1-min at 95% VO2 max).
  • Venous blood samples were analyzed pre- and post-exercise (immediately, 30, 60 min).
  • Lymphocyte cultures were assessed for mitogen response; T-lymphocytes (CD4+, CD8+) were isolated via magnetic separation.

Related Experiment Videos

Main Results:

  • Total lymphocyte mitogen response decreased immediately post-exercise, recovering by 30 min.
  • Pure T-lymphocyte (CD4+, CD8+) mitogen response remained unchanged.
  • Lymphocyte composition shifted post-exercise: increased natural killer (NK) cells (CD56+) and T-suppressor cells (CD8+), decreased T-helper cells (CD4+).

Conclusions:

  • Intensive interval exercise does not impair T-lymphocyte functional capacity.
  • Reduced total lymphocyte responsiveness post-exercise is linked to increased NK cells relative to T-cells.
  • Immune modulation during intense exercise involves shifts in lymphocyte subset populations.