Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Obesity, malic enzyme and aging--an animal experiment study]

H Martin1, M Benedix, C Bielitz

  • 1Institut für Klinische Chemie und Pathobiochemie, Leipzig.

Zeitschrift Fur Gerontologie Und Geriatrie
|November 1, 1996
PubMed
Summary

Experimental obesity in rats significantly alters malic enzyme activity, particularly in lipogenic organs like the liver and fat tissue. This enzyme

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

As compared to allopurinol, urate-lowering therapy with febuxostat has superior effects on oxidative stress and pulse wave velocity in patients with severe chronic tophaceous gout.

Rheumatology international·2013
Same author

Effects of guanyl nucleotides on CCKB receptor binding in brain tissue and continuous cell lines: a comparative study.

Neuropeptides·1995
Same author

Alzheimer's-associated phospho-tau epitope in human neuroblastoma cell cultures: up-regulation by fibronectin and laminin.

Neuroscience·1995
Same author

[Molecular mechanisms of hematopoietic stem cell differentiation].

Der Internist·1995
Same author

Biological zero in laser Doppler perfusion measurements: studies in neonates.

Acta paediatrica (Oslo, Norway : 1992)·1995
Same author

Effects of enhanced extracellular ammonia concentration on cultured mammalian retinal glial (Müller) cells.

Glia·1995

Area of Science:

  • Biochemistry
  • Physiology
  • Endocrinology

Context:

  • Investigates the impact of aging and experimentally induced obesity on malic enzyme activity in male Wistar rats.
  • Obesity was induced in newborn rats using Na(+)-L-glutamate injections.
  • Enzyme activity was assessed at 2, 6, and 18 months of age.

Purpose:

  • To determine how age and obesity affect malic enzyme (EC 1.1.1.40) activity across various organs.
  • To evaluate the glutamate-treated rat as a model for studying age-related diseases such as obesity and type II diabetes.

Summary:

  • In control rats, malic enzyme activity peaked at 6 months in the heart, liver, fat pad, and skeletal muscle, declining by 18 months.
  • Kidney activity decreased with age, while brain activity increased.

Related Experiment Videos

  • Glutamate-induced obese rats exhibited doubled malic enzyme activity in the liver and fat tissue compared to controls across all ages.
  • Clonidine treatment in obese rats reduced enzyme activity in liver and fat tissue, but it remained higher than in normal controls.

    • Impact:

    • Provides insights into the metabolic changes associated with aging and obesity at the enzymatic level.
    • Highlights the significant elevation of malic enzyme in lipogenic tissues of obese rats, suggesting altered lipid metabolism.
    • Suggests the glutamate-induced obese rat model warrants further investigation for studying age-associated metabolic disorders.