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Updated: Aug 10, 2026
07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
[Hyperthyroidism in TSH-producing hypophyseal adenoma]
1Klinik für Endokrinologie und Stoffwechselkrankheiten, Otto-von-Guericke-Universität Magdeburg.
Deutsche Medizinische Wochenschrift (1946)
|February 7, 1997
Summary
A TSH-producing pituitary adenoma, a rare cause of hyperthyroidism, was diagnosed in a man with unexplained symptoms. Surgical removal normalized thyroid hormone levels, resolving the condition.
Area of Science:
- Endocrinology
- Oncology
- Neurosurgery
Background:
- A 59-year-old male presented with a 5-year history of hyperthyroidism treated with thyrostatic drugs.
- Unexplained weight loss prompted imaging, revealing a pituitary mass.
Purpose of the Study:
- To investigate the etiology of persistent hyperthyroidism in a patient with a pituitary lesion.
- To determine the nature of the pituitary mass and its impact on thyroid function.
Main Methods:
- Computed tomography (CT) identified a pituitary space-occupying lesion.
- Hormonal assays revealed elevated thyroid hormone activities and non-suppressed thyroid-stimulating hormone (TSH).
- Octreotide scintigraphy and transsphenoidal surgery with immunohistochemical analysis were performed.
Main Results:
- The patient exhibited partial hypophyseal insufficiency alongside elevated TSH.
- Octreotide scintigraphy showed increased activity in the pituitary region.
- Histopathology confirmed a TSH-producing pituitary adenoma.
Conclusions:
- TSH-producing pituitary adenoma is a rare but significant cause of hyperthyroidism.
- Non-suppressed TSH in the context of hyperthyroidism warrants investigation for pituitary adenoma.
- Surgical resection of the adenoma resulted in a euthyroid state.
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