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[Hyperthyroidism in TSH-producing hypophyseal adenoma]

K Reschke1, T Rohrer, D Kopf

  • 1Klinik für Endokrinologie und Stoffwechselkrankheiten, Otto-von-Guericke-Universität Magdeburg.

Deutsche Medizinische Wochenschrift (1946)
|February 7, 1997
PubMed
Summary

A TSH-producing pituitary adenoma, a rare cause of hyperthyroidism, was diagnosed in a man with unexplained symptoms. Surgical removal normalized thyroid hormone levels, resolving the condition.

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Area of Science:

  • Endocrinology
  • Oncology
  • Neurosurgery

Background:

  • A 59-year-old male presented with a 5-year history of hyperthyroidism treated with thyrostatic drugs.
  • Unexplained weight loss prompted imaging, revealing a pituitary mass.

Purpose of the Study:

  • To investigate the etiology of persistent hyperthyroidism in a patient with a pituitary lesion.
  • To determine the nature of the pituitary mass and its impact on thyroid function.

Main Methods:

  • Computed tomography (CT) identified a pituitary space-occupying lesion.
  • Hormonal assays revealed elevated thyroid hormone activities and non-suppressed thyroid-stimulating hormone (TSH).
  • Octreotide scintigraphy and transsphenoidal surgery with immunohistochemical analysis were performed.

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Main Results:

  • The patient exhibited partial hypophyseal insufficiency alongside elevated TSH.
  • Octreotide scintigraphy showed increased activity in the pituitary region.
  • Histopathology confirmed a TSH-producing pituitary adenoma.

Conclusions:

  • TSH-producing pituitary adenoma is a rare but significant cause of hyperthyroidism.
  • Non-suppressed TSH in the context of hyperthyroidism warrants investigation for pituitary adenoma.
  • Surgical resection of the adenoma resulted in a euthyroid state.