Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Stem cells in the central nervous system

R McKay1

  • 1Laboratory of Molecular Biology, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.

Science (New York, N.Y.)
|April 4, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Renal cell carcinoma: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.

Annals of oncology : official journal of the European Society for Medical Oncology·2024
Same author

Resistance to COVID-19 vaccination has increased in Ireland and the United Kingdom during the pandemic.

Public health·2021
Same author

Injury to the Soft Tissues by Dentures.

The Dental register·2021
Same author

Investigating Tongue Strength and Endurance in Children Aged 6 to 11 Years.

Dysphagia·2019
Same author

Impact of symptomatic skeletal events on health-care resource utilization and quality of life among patients with castration-resistant prostate cancer and bone metastases.

Prostate cancer and prostatic diseases·2017
Same author

The defensive function of persecutory delusions: an investigation using the Implicit Association Test.

Acta neuropsychiatrica·2016
Same journal

A native sulfur deposit in Gale crater, Mars.

Science (New York, N.Y.)·2026
Same journal

Coordinated demise of harmful algal blooms.

Science (New York, N.Y.)·2026
Same journal

Genetic effects put into context.

Science (New York, N.Y.)·2026
Same journal

Bacteria share proteins to survive antibiotics.

Science (New York, N.Y.)·2026
Same journal

Impacts shaped Earth's first continents.

Science (New York, N.Y.)·2026
Same journal

Erratum for the Report "Covalently bonded single-molecule junctions with stable and reversible photoswitched conductivity" by C. Jia <i>et al</i>.

Science (New York, N.Y.)·2026
See all related articles

Multipotential stem cells in the vertebrate central nervous system can proliferate with mitogens and differentiate into neurons and glia. These findings are crucial for developing brain repair therapies.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Stem Cell Research

Background:

  • Multipotential cells exist in the vertebrate central nervous system (CNS).
  • These cells can be cultured and expanded in vitro.
  • Understanding their proliferation and differentiation is key to CNS development.

Purpose of the Study:

  • To investigate the proliferation and differentiation potential of multipotential cells in the CNS.
  • To explore the signaling logic governing stem cell differentiation into neurons and glia.
  • To assess the potential for cell integration in different brain regions.

Main Methods:

  • In vitro culture of multipotential cells from fetal and adult CNS.
  • Use of defined mitogens to stimulate cell proliferation.

Related Experiment Videos

  • In vivo cell transplantation studies to assess integration capacity.

    • Main Results:

    • Defined mitogens induce significant proliferation of multipotential cells in vitro.
    • Factors controlling differentiation into neurons and glia have been identified.
    • Neuroepithelial cells demonstrate integration potential across various brain regions upon transplantation.

    Conclusions:

    • Multipotential cells in the CNS possess significant proliferative and differentiation capabilities.
    • Signaling pathways regulating neurogenesis and gliogenesis are conserved from fetal to adult stages.
    • These findings provide a foundation for developing regenerative therapies for neurological disorders.