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Related Experiment Videos

Replacement fluids in plasmapheresis: cross-over comparative study

P Le Conte1, F Nicolas, C Adjou

  • 1Service de Réanimation Médicale, Centre Hôspitalier Universitaire, Nantes, France.

Intensive Care Medicine
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

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Adding dextran 40 or hydroxyethylstarch 6% to albumin 4% during plasmapheresis is well-tolerated and reduces fluid costs by 12%. These findings support cost-effective fluid replacement strategies in apheresis procedures.

Area of Science:

  • Nephrology
  • Critical Care Medicine
  • Transfusion Medicine

Background:

  • Plasmapheresis requires fluid replacement to maintain oncotic pressure.
  • Albumin 4% is a common replacement fluid, but its cost can be significant.
  • Alternative or additive solutions may offer cost benefits without compromising patient tolerance.

Purpose of the Study:

  • To compare the tolerance and cost-effectiveness of three plasmapheresis replacement fluid regimens.
  • To evaluate albumin 4% alone versus albumin 4% combined with dextran 40 or hydroxyethylstarch 6%.

Main Methods:

  • A single-center, randomized, cross-over study involving 27 patients and 225 plasmapheresis procedures.
  • Assessed hemodynamic tolerance and colloid oncotic pressure.
  • Compared serum protein concentrations post-procedure.

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Main Results:

  • All three fluid regimens demonstrated good hemodynamic tolerance.
  • Serum protein levels were lowest post-plasmapheresis in the albumin + hydroxyethylstarch group, followed by albumin + dextran 40.
  • Colloid oncotic pressure remained similar across all groups before and after the procedure.

Conclusions:

  • Combining hydroxyethylstarch 6% or dextran 40 with albumin 4% is clinically well-tolerated during plasmapheresis.
  • These combined regimens reduce the cost of substitution solutions by approximately 12%.
  • This suggests a more economical approach to fluid replacement in plasmapheresis.