Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Teratogenic study of doxycycline

A E Czeizel1, M Rockenbauer

  • 1Department of Human Genetics and Teratology, National Institute of Hygiene--World Health Organization Collaborating Centre for the Community Control of Hereditary Diseases, Budapest, Hungary.

Obstetrics and Gynecology
|April 1, 1997
PubMed
Summary

Doxycycline treatment during pregnancy shows minimal teratogenic risk to the fetus. This study suggests no contraindication for necessary doxycycline use in pregnant individuals, supporting fetal safety.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

IRF6 mutation screening in non-syndromic orofacial clefting: analysis of 1521 families.

Clinical genetics·2015
Same author

Association of certain chronic maternal diseases with the risk of specific congenital heart defects: a population-based study.

European journal of obstetrics, gynecology, and reproductive biology·2014
Same author

Phenolphthalein treatment in pregnant women and congenital abnormalities in their offspring: A population-based case-control study.

Drug discoveries & therapeutics·2012
Same author

Association of AXIN2 with non-syndromic oral clefts in multiple populations.

Journal of dental research·2012
Same author

Experience of the Hungarian Preconception Service between 1984 and 2010.

European journal of obstetrics, gynecology, and reproductive biology·2012
Same author

Possible association of folic acid supplementation during pregnancy with reduction of preterm birth: a population-based study.

European journal of obstetrics, gynecology, and reproductive biology·2009

Area of Science:

  • Obstetrics and Gynecology
  • Pharmacology
  • Teratology

Background:

  • Doxycycline is a commonly prescribed antibiotic.
  • Assessing medication safety during pregnancy is crucial for maternal and fetal health.
  • Previous studies on doxycycline's teratogenic potential have yielded mixed results.

Purpose of the Study:

  • To evaluate the potential teratogenic risk associated with doxycycline exposure during human pregnancy.
  • To determine if doxycycline treatment during gestation increases the incidence of congenital abnormalities.

Main Methods:

  • A large population-based case-control study was conducted using data from the Hungarian Case-Control Surveillance of Congenital Abnormalities (1980-1992).
  • Infants with congenital abnormalities were compared with healthy controls.

Related Experiment Videos

  • Paired analysis was performed to assess the association between maternal doxycycline treatment and fetal outcomes.

    • Main Results:

    • A slightly higher rate of doxycycline use was observed in mothers of infants with congenital abnormalities (0.30%) compared to controls (0.19%), though this difference was statistically significant (P = .01).
    • However, detailed case-control pair analysis did not reveal a significantly increased risk of specific congenital abnormalities following doxycycline treatment in the second and third months of gestation.
    • The overall findings suggest a low teratogenic risk.

    Conclusions:

    • Doxycycline treatment during pregnancy appears to pose very little, if any, teratogenic risk to the developing fetus.
    • There is no apparent contraindication for the necessary use of doxycycline in pregnant patients.
    • This study supports the cautious use of doxycycline when indicated during pregnancy.