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Pharmacokinetics and concentration-effect relationship after propofol infusion
1Department of Anaesthesia and Intensive Care, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong.
Acta Anaesthesiologica Sinica
|September 1, 1996
Summary
This study models propofol pharmacokinetics (PK) for predicting eye-opening times. The derived PK model accurately estimates propofol concentration during recovery from anesthesia.
Area of Science:
- Anesthesiology
- Pharmacokinetics
- Pharmacodynamics
Background:
- Investigated propofol pharmacokinetics (PK) and concentration-effect relationship.
- Aimed to develop a predictive model for eye-opening time post-propofol infusion.
Purpose of the Study:
- To derive a pharmacokinetic model for propofol infusion.
- To predict propofol concentration at the time of eye opening.
Main Methods:
- Propofol anesthesia induced and maintained using a Computer Controlled Infusion Pump in 34 patients.
- Arterial blood samples collected during recovery to derive a new PK model.
- Model used to predict propofol concentration at eye opening.
Main Results:
- Central volume of distribution: 0.228 L/kg.
- Inter-compartment transfer rate constants (min-1): k10=0.166, K12=0.091, k13=0.124, k21=0.045, k31=0.0098.
- Predicted concentration for 50% response (eye opening): 0.98 microgram/ml.
Conclusions:
- Propofol PK parameters during anesthesia differ from those during recovery.
- Propofol PK during recovery from infusion is similar to that after a bolus dose.
- Real-time estimation of blood propofol concentration aids anesthesia recovery monitoring.