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Serotonin2A receptor gene polymorphism in mood disorders

H Y Zhang1, T Ishigaki, K Tani

  • 1Department of Psychiatry, Hamamatsu University School of Medicine, Shizuoka, Japan.

Biological Psychiatry
|April 1, 1997
PubMed
Summary

The serotonin 5-HT2A receptor gene may influence mood disorders. A specific C allele at position 102 was more common in depressive disorders and linked to earlier onset, suggesting a role in disease development.

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Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Serotonin (5-HT) system genes, including 5-HT receptors, are implicated in mood disorders.
  • Genetic variations may contribute to the pathophysiology of depressive and bipolar disorders.

Purpose of the Study:

  • To investigate the role of the serotonin 5-HT2A receptor gene in mood disorders.
  • To identify potential genetic polymorphisms associated with depressive and bipolar disorders.

Main Methods:

  • Sequencing of 5-HT2A receptor exons and adjacent introns in 102 mood disorder patients.
  • Analysis of allele frequencies and correlation with clinical characteristics.
  • Comparison with healthy control subjects.

Main Results:

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  • A C to T substitution at position 102 in exon 1 of the 5-HT2A receptor gene was confirmed.
  • The C allele frequency was significantly higher in patients with depressive disorders compared to bipolar disorder patients and controls.
  • Heterozygosity for the C and T alleles at position 102 was associated with a lower mean age of onset.

Conclusions:

  • The serotonin 5-HT2A receptor gene, specifically the C allele at position 102, may be associated with an increased risk and earlier onset of depressive disorders.
  • No other disease-specific polymorphisms were identified in the studied regions of the 5-HT2A receptor gene.