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Two mosaic-YY males carrying asymmetric Y chromosomes
L Zelante1, B Dallapiccola, S Calvano
1Servizio di Genetica Medica, IRCCS, Ospedale CSS San Giovanni Rotondo, Italy.
Clinical Genetics
|January 1, 1997
Abstract:
Two patients were referred because of oligospermia and azospermia, respectively. Karyotypic analysis revealed two mosaic-YY males carrying asymmetric Y chromosomes. To our knowledge, no instance of double unequal Y chromosomes has been reported so far in human males. Results of fluorescent in situ hybridization (FISH) studies in spermatozoa from one of these patients revealed a significantly high number of hyperaploid spermatozoa.