Acute acalculous cholecystitis with a decrease in CD4/CD8 ratio
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Updated: Nov 2, 2026

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Published on: January 31, 2025
S Ikeda1, W Kimura, N Futakawa
1First Department of Surgery, University of Tokyo, Japan.
Abstract:
Acute acalculous cholecystitis (AAC) usually occurs in the elderly and in those with severe pre-existing pathological conditions. However, there have recently been reports of AAC in relatively young immunosuppressed patients, such as those with acquired immunodeficiency syndrome (AIDS). We report here a 27-year-old woman with AAC who received an emergent cholecystectomy. Although anti-human immunodeficiency virus antibody (anti-HIV) was not detected, a decrease in the CD4/CD8 ratio in sera was found. This rare case of AAC in a patient with decreased CD4/CD8 ratio who showed no other related diseases suggests that surgeons should keep in mind the possible presence of immunosuppression in this condition.
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