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Methazolamide-induced delirium

M Cyr¹, S C Laizure, C M daCunha

¹College of Pharmacy, University of Tennessee, Memphis, USA.

Pharmacotherapy

|March 1, 1997

Summary

This summary is machine-generated.

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A 74-year-old man experienced delirium after starting methazolamide. Symptoms resolved after discontinuing the drug, marking the first reported case without metabolic imbalance.

Area of Science:

Pharmacology
Neurology
Geriatrics

Background:

Methazolamide is a carbonic anhydrase inhibitor used to treat glaucoma and edema.
Adverse drug reactions can significantly impact patient health and treatment outcomes.

Observation:

A 74-year-old male developed acute delirium, including psychosis, incontinence, lethargy, and disorientation, two days after initiating oral methazolamide.
The patient's symptoms persisted for 25 days despite extensive medical interventions and drug regimen adjustments.

Findings:

Discontinuation of methazolamide led to complete resolution of delirium symptoms within one week.
This case represents the first documented instance of methazolamide-induced delirium occurring in the absence of a concurrent metabolic imbalance.

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Implications:

Clinicians should consider methazolamide as a potential cause of delirium, even without identifiable metabolic disturbances.
Early recognition and drug withdrawal are crucial for managing methazolamide-associated neurotoxicity.
This finding highlights the importance of comprehensive medication review in elderly patients presenting with unexplained delirium.