Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Neurobehavioral consequences of arousals

D K Chugh1, T E Weaver, D F Dinges

  • 1Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.

Sleep
|December 1, 1996
PubMed
Summary

Obstructive sleep apnea syndrome (OSAS) causes neurobehavioral deficits due to sleep fragmentation, not just arousal rates. Chronic sleep fragmentation increases sleep pressure, leading to daytime sleepiness and impaired cognition.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Association of peri-operative prescription of non-steroidal anti-inflammatory drugs with continued prescription of opioids after total knee arthroplasty: a retrospective claims-based cohort study.

Anaesthesia·2024
Same author

Bacterial killing is enhanced by exogenous administration of lysozyme in the lungs.

Respiratory medicine and research·2019
Same author

520-d Isolation and confinement simulating a flight to Mars reveals heightened immune responses and alterations of leukocyte phenotype.

Brain, behavior, and immunity·2014
Same author

Proteolytic generation and aggregation of peptides from transmembrane regions: lung surfactant protein C and amyloid beta-peptide.

Cellular and molecular life sciences : CMLS·2004
Same author

Sleep loss reduces diurnal rhythm amplitude of leptin in healthy men.

Journal of neuroendocrinology·2003
Same author

Efficacy of the topical nasal steroid budesonide on improving sleep and daytime somnolence in patients with perennial allergic rhinitis.

Allergy·2003

Area of Science:

  • Sleep Medicine
  • Neuroscience
  • Pulmonology

Background:

  • Neurobehavioral deficits in obstructive sleep apnea syndrome (OSAS) are often linked to respiratory disturbance and arousal rates.
  • Sleep-disordered breathing involves sleep infrastructure changes that may cause cumulative waking deficits.

Purpose of the Study:

  • To investigate the relationship between sleep fragmentation and neurobehavioral deficits in OSAS.
  • To explore how chronic sleep fragmentation impacts sleep architecture and homeostatic sleep drive.

Main Methods:

  • Analysis of polysomnographic data from 1,521 OSAS patients.
  • Comparison with experimental sleep fragmentation paradigms in healthy individuals.

Main Results:

  • Increasing arousal indices in OSAS patients correlated with increased stage 1 sleep duration and reduced total sleep time.
  • Chronic sleep fragmentation, from apneas or stimuli, increases homeostatic sleep pressure.
  • Observed phenomena include increased arousal threshold, rapid sleep return, fewer awakenings, sleep inertia, amnesia, and daytime sleepiness.

Conclusions:

  • Sleep fragmentation, not solely arousal frequency, contributes significantly to OSAS neurobehavioral deficits.
  • Elevated homeostatic sleep drive is influenced by arousal frequency and chronicity of sleep fragmentation.
  • Existing experimental models may not fully capture the chronic nature of sleep fragmentation in OSAS.

Related Experiment Videos