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Effect of the basidiomycete Poria cocos on experimental dermatitis and other inflammatory conditions
M J Cuellar1, R M Giner, M C Recio
1Departament de Farmacologia, Facultat de Farmacia, Universitat de València, Spain.
Chemical & Pharmaceutical Bulletin
|March 1, 1997
Abstract:
The hydroalcoholic extract from P. cocos was examined for oral and topical anti-inflammatory activities. It proved to be active against carrageenan, arachidonic acid, tetradecanoyl phorbol acetate (TPA) acute edemas, TPA chronic inflammation and oxazolone delayed hypersensitivity in mice. Two lanostane-type triterpenes were isolated and identified by spectroscopic methods as dehydrotumulosic and pachymic acids. Their ID50 on acute TPA edema was 4.7 x 10(-3) and 6.8 x 10(-4) mumol/ear, respectively.