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[Bladder carcinoma presenting with hypercalcemia: a case report]

Y Maeda1, H Nakazawa, N Yoshimura

  • 1Department of Urology, Tokyo Women's Medical College.

Hinyokika Kiyo. Acta Urologica Japonica
|February 1, 1997
PubMed
Summary
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A bladder tumor caused severe hypercalcemia in a 47-year-old woman. Despite treatment and surgery, the advanced cancer led to her death seven months later.

Area of Science:

  • Oncology
  • Urology
  • Endocrinology

Background:

  • Hypercalcemia is a common complication of malignancy, often associated with poor prognosis.
  • Parathyroid hormone-related protein (PTHrP) is a frequent mediator of cancer-induced hypercalcemia.

Observation:

  • A 47-year-old woman presented with symptoms of nausea, vomiting, and weight loss.
  • Imaging revealed an invasive bladder tumor with calcification.
  • Laboratory tests showed significant hypercalcemia (20.6 mg/dl) and elevated PTHrP (29.9 pmol/l).

Findings:

  • The bladder tumor was identified as the source of PTHrP production, causing hypercalcemia.
  • Treatment with pamidronate and fluid resuscitation normalized calcium levels.
  • Histopathology confirmed advanced transitional cell carcinoma (G3, pT4pN2M0, stage IV).

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Implications:

  • This case highlights the importance of investigating hypercalcemia in patients with bladder cancer.
  • PTHrP measurement can aid in diagnosing humoral hypercalcemia of malignancy.
  • Despite aggressive management, advanced bladder cancer with hypercalcemia has a poor prognosis.