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Related Experiment Videos

Apoptosis

T A Fleisher1

  • 1Immunology Service, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Apoptosis, a form of programmed cell death, is vital for immune function and tissue balance. Defects in apoptosis contribute to diseases like cancer and autoimmune disorders, impacting cell survival.

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Area of Science:

  • Cell Biology
  • Immunology
  • Pathology

Background:

  • Apoptosis, or programmed cell death, is a fundamental physiological process.
  • Its significance in cellular homeostasis and immune system regulation is increasingly recognized.

Purpose of the Study:

  • To introduce the basic concept of apoptosis.
  • To explore the role of apoptosis in immune function.
  • To examine the contribution of apoptosis to various clinical disorders.

Main Methods:

  • Author's clinical experience with autoimmune syndromes linked to apoptosis defects.
  • Critical review of recent literature on apoptosis in health and disease.

Main Results:

  • Apoptosis is crucial for immune development, immune response control, and T cell effector function.

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  • Defects in apoptosis are implicated in diseases such as cancer, where cells evade elimination.
  • Altered apoptosis is emerging as a factor in autoimmune and neurodegenerative disorders.

    • Conclusions:

    • Apoptosis is central to maintaining normal tissue homeostasis.
    • Dysregulation of apoptosis (either increased or decreased cell survival) is linked to diverse clinical diseases.