Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fumonisin mycotoxicosis in broilers: plasma proteins and coagulation modifications

Y Espada1, R Ruiz de Gopegui, C Cuadradas

  • 1Faculty of Veterinary Science, Universidad Autónoma Barcelona, Spain.

Avian Diseases
|January 1, 1997
PubMed
Summary

Fumonisin B1 (FB1) intoxication in chickens can alter blood clotting and serum proteins, even at low doses. Recovery periods showed no lasting effects on these parameters in young chicks.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Host-driven subspeciation in the hedgehog fungus, <i>Trichophyton erinacei</i>, an emerging cause of human dermatophytosis.

Persoonia·2024
Same author

Pulmonary carcinoma associated with cystic airspaces in two dogs.

The Journal of small animal practice·2021
Same author

Intraspecific variability of growth and ochratoxin A production by Aspergillus carbonarius from different foods and geographical areas.

International journal of food microbiology·2019
Same author

New Ochratoxigenic Species in the Genus Aspergillus.

Journal of food protection·2019
Same author

Mycoflora and Aflatoxin-Producing Strains in Animal Mixed Feeds.

Journal of food protection·2019
Same author

Impact of some environmental factors on growth and ochratoxin A production by Aspergillus niger and Aspergillus welwitschiae.

International journal of food microbiology·2018

Area of Science:

  • Animal Science
  • Toxicology
  • Biochemistry

Background:

  • Fumonisin B1 (FB1) is a mycotoxin produced by Fusarium species.
  • FB1 contamination in animal feed is a significant concern for poultry health.
  • Understanding FB1's toxicological effects on chickens is crucial for food safety.

Purpose of the Study:

  • To evaluate the effects of FB1 intoxication on hemostasis and serum proteins in broiler chicks.
  • To determine if low doses of FB1 or FB1 from contaminated feed impact these parameters.
  • To assess the reversibility of FB1-induced changes after a recovery period.

Main Methods:

  • Three experiments were conducted using 2-day-old broiler chicks.
  • Chicks were fed diets containing pure FB1 or Fusarium moniliforme culture material with FB1 at varying doses and durations.

Related Experiment Videos

  • Blood samples were analyzed for prothrombin time, plasma fibrinogen, antithrombin III, serum albumin, and serum globulins.

    • Main Results:

    • FB1 intoxication led to decreased prothrombin time and increased antithrombin III activity.
    • Serum albumin concentration decreased while serum globulins increased in chicks fed FB1-contaminated feed.
    • Chicks allowed to recover for 5 weeks showed no significant differences in hemostasis or serum proteins compared to controls.

    Conclusions:

    • Low doses of pure FB1 (10 mg/kg) and FB1 from contaminated feed (30 mg/kg) can negatively affect hemostasis and serum protein profiles in young chickens.
    • The observed alterations in hemostasis and serum proteins are not permanent and can be reversed after a recovery period.
    • These findings highlight the potential risks of FB1 exposure in poultry farming and the importance of feed monitoring.