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Related Experiment Videos

Measles reimmunization in children seronegative after initial immunization

G A Poland1, R M Jacobson, A M Thampy

  • 1Mayo Vaccine Research Group, Mayo Clinic and Foundation, Rochester, Minn 55905, USA.

JAMA
|April 9, 1997
PubMed
Summary

Reimmunizing children who lacked measles antibodies after one dose resulted in 81.5% seroconversion. This supports a two-dose measles vaccine strategy for community immunity.

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Area of Science:

  • Pediatric Infectious Diseases
  • Immunology
  • Public Health

Background:

  • Measles remains a significant public health concern globally.
  • Initial measles vaccination aims to induce protective immunity.
  • A subset of children may not develop sufficient measles antibodies after a single dose.

Purpose of the Study:

  • To assess the efficacy of measles reimmunization in children lacking measles antibodies post-initial vaccination.
  • To identify factors influencing seroconversion after a second measles vaccine dose.

Main Methods:

  • A prospective clinical trial involving 130 schoolchildren who received the Moraten measles vaccine 4-11 years prior.
  • Participants identified as seronegative or equivocal after the first dose were reimmunized.

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  • Measles-specific IgG antibodies were measured using an enzyme-linked immunoassay (EIA) at least 6 weeks post-reimmunization.

    • Main Results:

    • 81.5% (106/130) of reimmunized children achieved seropositive measles antibody levels.
    • 18.5% (24/130) remained seronegative after the second dose.
    • Younger age at initial immunization and longer intervals since the first dose were associated with lower seroconversion rates.

    Conclusions:

    • A two-dose measles vaccination strategy achieves high seroprevalence (98.2%) in children.
    • The findings support current public health policies for a two-dose measles immunization schedule.
    • This strategy is crucial for maintaining community-wide measles immunity.