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Related Experiment Videos

Leptin-induced decrease in food intake is not associated with changes in gastric emptying in lean mice

M D Barrachina1, V Martínez, J Y Wei

  • 1Center for Ulcer Research and Education, West Los Angeles Veteran's Affairs Medical Center, California 90073, USA.

The American Journal of Physiology
|March 1, 1997
PubMed
Summary
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A single injection of leptin (LEP) in mice reduces food intake within 5 hours but does not affect gastric emptying. Rats showed no response to leptin

Area of Science:

  • Endocrinology
  • Neuroscience
  • Physiology

Background:

  • Leptin (LEP) is a hormone known to regulate body weight and energy balance.
  • Chronic leptin treatment reduces food intake in obese and lean animal models.
  • The acute effects of leptin on food intake and gastric emptying require further investigation.

Purpose of the Study:

  • To investigate the acute effects of a single intraperitoneal injection of recombinant mouse leptin on food intake and gastric emptying in lean mice.
  • To determine the responsiveness of Sprague-Dawley rats to acute leptin administration regarding food intake.

Main Methods:

  • Lean mice (C57BL/6) and Sprague-Dawley rats were fasted for 18-20 hours.
  • Mice received a single intraperitoneal injection of recombinant mouse leptin (0.12 mg/kg).

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  • Food intake and gastric emptying of a solid nutrient meal were measured at various time points postinjection.

    • Main Results:

    • Leptin significantly reduced food intake in mice, with peak inhibition observed at 5 hours postinjection.
    • No significant change in food consumption was noted at 1 hour postinjection in mice.
    • Leptin did not alter the 4-hour gastric emptying rate in mice.
    • Sprague-Dawley rats did not exhibit modified food intake following leptin injection, even at a 10-fold higher dose than effective in mice.

    Conclusions:

    • A single intraperitoneal injection of leptin acutely reduces food intake in lean mice within 5 hours.
    • Leptin administration does not influence gastric emptying in lean mice.
    • Sprague-Dawley rats appear unresponsive to the acute food intake-reducing effects of leptin at the tested doses.