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Cloning and functional expression of the rat brain KIR6.2 channel
1Department of Physiology and Biophysics, Faculty of Medicine, Kyoto University, Japan. takano@med.kyoto.u.ac.jp
Abstract:
We obtained cDNA encoding KIR6.2 channel from the rat brain cDNA library. The reconstituted K+ channel with KIR6.2 and SUR1 genes retained properties similar to those reported in the native ATP-sensitive K+ channel including run-down and recovery of channel activity. When KIR6.2 was co-expressed with CFTR or MDR1, no K+ channel activity was recorded.
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