Antiphospholipid antibodies: a threat throughout pregnancy

Antiphospholipid syndrome (APS) has been associated with recurrent pregnancy loss. The exact pathophysiologic mechanism in unclear but may be associated with an imbalance in the prostacyclin/ thromboxane ratio, which results in vasoconstriction and platelet aggregation. Antiphospholipid syndrome is diagnosed through laboratory tests and clinical assessment. Various regimens are used to treat women who have APS. The purpose of this article is to review this disorder and discuss indications for testing, diagnosis and treatment, and nursing implications.