Serum PSA levels at 6 month after surgery, TURP or Doxazosin therapy for BPH

In 180 men with BPH, aged 50-84 (mean 65) yrs. PSA levels were determined before and at 6 mo. after either transvesical removal of the adenoma (TRA, Group 1, n = 65), TURP (Group 2, n = 51) or after 6 mo. Doxazosin therapy (Group 3, n = 64). Fine-needle biopsy, performed when the baseline PSA exceeded 10 ng/ml, as well as pathologic examination of specimens taken during TRA and TURP confirmed BPH in all cases. After all modes of treatment the decrease in PSA values was largest in Group 1 and smallest in Group 3. This probably reflects the degree of completeness of adenoma removal. However, all therapeutic modalities including Doxazosin pharmacotherapy ensured PSA normalization, despite the persistence of the adenoma.