Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Senile chorea: a multicenter prospective study

P J García Ruiz1, E Gómez-Tortosa, A del Barrio

  • 1Department of Neurology and Genetics, Fundación Jiménez Díaz, Madrid, Spain.

Acta Neurologica Scandinavica
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Search for long-lived doubly charged Higgs bosons in pp collisions at sqrt[s] = 1.96 TeV.

Physical review letters·2005
Same author

Measurement of B(t --> Wb)/B(t--> Wq) at the collider detector at fermilab.

Physical review letters·2005
Same author

Search for new physics using high-mass tau pairs from 1.96 TeV pp collisions.

Physical review letters·2005
Same author

Multiple primary digital apocrine sweat gland carcinosarcoma in a cat.

The Veterinary record·2005
Same author

Measurement of the W(+)W(-) production cross section in pp collisions at square root[s]=1.96 TeV using dilepton events.

Physical review letters·2005
Same author

Search for anomalous kinematics in tt dilepton events at CDF II.

Physical review letters·2005
Same journal

Editorial.

Acta neurologica Scandinavica·2022
Same journal

Advances in sudden unexpected death in epilepsy.

Acta neurologica Scandinavica·2022
Same journal

Non-convulsive seizures and non-convulsive status epilepticus in neuro-intensive care unit.

Acta neurologica Scandinavica·2022
Same journal

Positron emission tomography in autoimmune encephalitis: Clinical implications and future directions.

Acta neurologica Scandinavica·2022
Same journal

Seizure detection based on wearable devices: A review of device, mechanism, and algorithm.

Acta neurologica Scandinavica·2022
Same journal

Walking confidence and perceived locomotion ability explain participation after stroke: A cross-sectional experimental study.

Acta neurologica Scandinavica·2022
See all related articles

Senile chorea (SC) may be indistinguishable from late-onset Huntington's disease (HD) without genetic testing. Some SC cases are actually sporadic HD, highlighting the need for genetic analysis to differentiate these conditions.

Area of Science:

  • Neurology
  • Genetics

Background:

  • Senile chorea (SC) presents as late-onset, generalized chorea without a family history or dementia.
  • Its distinction from late-onset Huntington's disease (HD) with an undetected family history remains unclear.

Observation:

  • A prospective, multicenter study identified six suspected SC cases.
  • Investigations included lab tests, MRI, neuropsychological assessments, and IT15 gene analysis.
  • Abnormal CAG repeat expansion was found in three patients.

Findings:

  • Neuropsychological deficits, particularly in visuospatial and prefrontal tasks, were observed in all six patients.
  • Three patients were diagnosed with late-onset HD, while the others had SC.
  • Clinical differentiation between SC and late-onset sporadic HD was not possible without genetic analysis.

Related Experiment Videos

Implications:

  • This study supports the existence of SC as a distinct entity.
  • Genetic testing is crucial for differentiating SC from late-onset sporadic HD.
  • Some suspected SC cases are reclassified as late-onset sporadic HD based on genetic findings.