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Hemangioma in twins

D S Cheung1, M L Warman, J B Mulliken

  • 1Division of Plastic Surgery, Children's Hospital, Boston, MA 02115, USA.

Annals of Plastic Surgery
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Hereditary factors are not the primary cause of infantile hemangioma. Environmental influences, combined with female sex, fair skin, and Caucasian ethnicity, likely trigger this common infant tumor.

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Area of Science:

  • Pediatric Dermatology
  • Genetics and Pathogenesis of Infantile Hemangioma

Background:

  • Infantile hemangioma (IH) is the most common tumor of infancy.
  • The exact pathogenesis of IH remains unclear, with ongoing debate regarding the roles of genetic and environmental factors.

Observation:

  • A cohort study reviewed 118 twin pairs with infantile hemangioma to assess clinical characteristics and etiological factors.
  • Data on zygosity, race, gender, lesion distribution, age of onset, and complications were collected via parental questionnaires.
  • Concordance rates for IH in monozygotic and dizygotic twins were analyzed, with no statistically significant differences observed between groups.

Findings:

  • The study found no significant difference in concordance rates between monozygotic and dizygotic twins for infantile hemangioma.

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  • This suggests that hereditary factors are not paramount in the etiology of IH.
  • Factors such as being female, fair-skinned, Caucasian, and having a positive family history may lower the threshold for hemangiogenesis, allowing extragenetic factors to trigger IH development.

    • Implications:

    • The findings indicate that environmental factors play a significant role in the pathogenesis of infantile hemangioma.
    • Understanding these triggers can inform future research into prevention and targeted therapies for IH.
    • This study highlights the complex interplay between genetic predisposition and environmental influences in the development of this common pediatric vascular anomaly.