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Updated: Oct 9, 2026

Investigation of Synaptic Tagging/Capture and Cross-capture using Acute Hippocampal Slices from Rodents
Published on: September 4, 2015
Induction of heterosynaptic and homosynaptic LTD in hippocampal sub-regions in vivo
1Department of Psychology, University of Otago, Dunedin, New Zealand.
Abstract:
Establishing the conditions under which long-term depression (LTD) an be induced in vitro remains an important empirical issue. While heterosynaptic LTD is readily elicited in the hippocampus in vivo, the induction of homosynaptic LTD has been more problematic, both in CA1 and in the dentate gyrus. Our work has demonstrated, however, that 900 pulses at 1 Hz will reliably induce LTD in both area CA1 and the dentate gyrus of pentobarbital-anesthetized animals, when the stimulating and recording electrodes are in close proximity to each other.
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