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Endothelin B receptor-like immunoreactivity is associated with LHRH-immunoreactive fibers in the rat hypothalamus
T Yamamoto1, H Suzuki, H Uemura
1Department of Biology, Kanagawa Dental College, Yokosuka, Japan.
Neuroscience Letters
|February 21, 1997
Abstract:
Antisera were raised against amino-acid residues 425-439 of the rat endothelin B (ETB) receptor. Massive ETB receptor immunoreactive fibers were observed in the median eminence and organum vasculosum lamina terminalis of rats. Double labeling studies with anti-luteinizing hormone-releasing hormone (LHRH) antiserum revealed that ETB receptor-like immunoreactivity associated with LHRH-immunoreactive fibers in these areas. However, ETB receptor-like immunoreactivity was not detected in LHRH-immunoreactive somata. This result suggests that endothelin affects the LHRH neuronal systems via ETB receptors on the axon at the terminal field.