Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms underlying memory impairment in schizophrenia

G Brébion1, X Amador, M J Smith

  • 1New York State Psychiatric Institute, College of Physicians and Surgeons, Columbia University, NY, USA.

Psychological Medicine
|March 1, 1997
PubMed
Summary

Schizophrenia patients show significant verbal memory deficits, particularly in encoding information. Their ability to use deep encoding strategies is impaired, impacting overall memory performance.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Application of an Intermittency Model for Laminar, Transitional, and Turbulent Internal Flows.

Journal of fluids engineering·2021
Same author

Global brain asymmetry is increased in schizophrenia and related to avolition.

Acta psychiatrica Scandinavica·2017
Same author

Schizophrenia patients with high intelligence: A clinically distinct sub-type of schizophrenia?

European psychiatry : the journal of the Association of European Psychiatrists·2015
Same author

Decreased processing speed might account for working memory span deficit in schizophrenia, and might mediate the associations between working memory span and clinical symptoms.

European psychiatry : the journal of the Association of European Psychiatrists·2014
Same author

Source memory errors in schizophrenia, hallucinations and negative symptoms: a synthesis of research findings.

Psychological medicine·2012
Same author

The emerging therapeutic role of RNA interference in disorders of the central nervous system.

Clinical pharmacology and therapeutics·2011

Area of Science:

  • Cognitive Psychology
  • Neuroscience
  • Psychiatry

Background:

  • Verbal memory impairments are common in schizophrenia.
  • An encoding deficit is a hypothesized mechanism underlying these impairments.

Purpose of the Study:

  • To investigate verbal memory mechanisms in schizophrenia.
  • To specifically examine the encoding deficit hypothesis.
  • To differentiate between encoding, storage, and retrieval functions.

Main Methods:

  • Administered a verbal memory task to 38 schizophrenia patients and 38 controls.
  • Assessed encoding using organizable vs. non-organizable lists (deep vs. superficial encoding).
  • Investigated early storage with varying delays and retrieval using cues.

Related Experiment Videos

Main Results:

  • Schizophrenia patients utilized list organization less than controls.
  • Deep encoding was impaired in patients; superficial encoding was less efficient.
  • Storage and retrieval functions showed no significant differences between groups.

Conclusions:

  • A major encoding deficit exists in schizophrenia patients.
  • Impaired deep encoding and reduced superficial encoding efficiency contribute to memory problems.
  • Memory performance is linked to the depth of encoding strategies.