Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Altered dopamine function in pathological gambling

C Bergh1, T Eklund, P Södersten

  • 1Department of Clinical Neuroscience and Family Medicine, Karolinska Institute, Huddinge, Sweden.

Psychological Medicine
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ART in Europe, 2020: results generated from European registries by ESHRE†.

Human reproduction (Oxford, England)·2025
Same author

Cumulative live birth rates in a freeze-all or fresh transfer strategy after one ART cycle in ovulatory women.

Reproductive biomedicine online·2025
Same author

Survey on ART and IUI: legislation, regulation, funding, and registries in European countries-an update.

Human reproduction (Oxford, England)·2024
Same author

No major differences in perinatal and maternal outcomes between uninterrupted embryo culture in time-lapse system and conventional embryo culture.

Human reproduction (Oxford, England)·2023
Same author

Puberty disorders among ART-conceived singletons: a Nordic register study from the CoNARTaS group.

Human reproduction (Oxford, England)·2022
Same author

ART in Europe, 2018: results generated from European registries by ESHRE.

Human reproduction open·2022
Same journal

Replicable subcortical alterations linked to neurological soft signs in schizophrenia spectrum disorders.

Psychological medicine·2026
Same journal

Distinct and common subcortical functional connectivity revealed across three major psychiatric disorders - CORRIGENDUM.

Psychological medicine·2026
Same journal

Adversity as the key feature: neuroimaging profiles of subtypes from multiple depression risk factors.

Psychological medicine·2026
Same journal

Sorting the mind: cognitive enhancement through transcutaneous auricular vagus nerve stimulation: a systematic review and meta-analysis.

Psychological medicine·2026
Same journal

Depression and aging: insights from brain age prediction models.

Psychological medicine·2026
Same journal

An integrative NLP framework identifies multilevel linguistic phenotypes of schizophrenia across tasks.

Psychological medicine·2026
See all related articles

Pathological gambling may involve altered neurotransmitter systems. Dopamine and noradrenaline levels are changed in gamblers, suggesting a role in reward and attention.

Area of Science:

  • Neuroscience
  • Psychiatry
  • Addiction Research

Background:

  • Pathological gambling is a complex disorder.
  • Investigating the underlying neurobiology is crucial for understanding and treatment.

Purpose of the Study:

  • To examine alterations in monoaminergic neurotransmission in pathological gamblers.
  • To identify specific neurotransmitter system changes associated with the disorder.

Main Methods:

  • Cerebrospinal fluid (CSF) was collected from pathological gamblers and control subjects.
  • Levels of monoamines (dopamine, noradrenaline, serotonin) and their metabolites were quantified.

Main Results:

  • A significant decrease in dopamine levels was observed in pathological gamblers.

Related Experiment Videos

  • Elevated levels of dopamine metabolites (3,4-dihydroxyphenylacetic acid, homovanilic acid) and noradrenaline metabolite (3-methoxy-4-hydroxyphenylglycol) were found.
  • Serotonin and its metabolite levels remained unchanged between groups.

    • Conclusions:

    • The findings suggest altered dopaminergic and noradrenergic system function in pathological gambling.
    • These changes may be linked to the modulation of reward processing and selective attention.
    • Further research into these neurochemical pathways could inform therapeutic strategies.