Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Low-voltage-activated T-type Ca2+ channels

S I Ertel1, E A Ertel

  • 1Sundgau Medical Writers, Habsheim, France.

Trends in Pharmacological Sciences
|February 1, 1997
PubMed
Summary

Research on T channels, crucial for cell function, is intense despite slow progress. New drugs and cloning efforts promise to overcome previous research barriers.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pulmonary arterial hypertension: a comparison between children and adults.

The European respiratory journal·2011
Same author

The pharmacology of bosentan.

Expert opinion on investigational drugs·2005
Same author

Pharmacological properties of Ca(V)3.2, a low voltage-activated Ca2+ channel cloned from human heart.

Naunyn-Schmiedeberg's archives of pharmacology·2000
Same author

Nodulisporic acid opens insect glutamate-gated chloride channels: identification of a new high affinity modulator.

Biochemistry·2000
Same author

Nomenclature of voltage-gated calcium channels.

Neuron·2000
Same author

Pharmacokinetics and pharmacodynamics of sibrafiban alone or in combination with ticlopidine and aspirin.

British journal of clinical pharmacology·2000

Area of Science:

  • Physiology
  • Molecular Biology
  • Pharmacology

Background:

  • T channels, a type of calcium channel, have roles that are less understood than other calcium channels.
  • Research progress has been hindered by small current amplitudes, limited pharmacological tools, apparent heterogeneity, and the lack of a cloned channel.
  • Despite challenges, T channels are implicated in subtle modulatory physiological actions.

Framework:

  • Workshop discussions highlighted intense research interest in T channels.
  • Identified key challenges limiting T channel research: small current amplitude, lack of specific drugs, heterogeneity, and absence of a cloned channel.

Implementation:

  • Development of new, selective pharmacological tools like mibefradil and next-generation compounds.
  • Advancements in molecular biology suggest imminent cloning of T channels.

Implications:

  • Overcoming current research barriers will accelerate T channel understanding.
  • New tools and cloned channels will enable deeper insights into T channel physiological roles.
  • Expected breakthroughs will significantly advance the study of T channels and their functions.

Related Experiment Videos