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Cyclopia: craniofacial appearance on MR and three-dimensional CT
D P Liu1, D M Burrowes, M N Qureshi
1Department of Radiology, beth Israel Medical Center, New York, NY 10003, USA.
AJNR. American Journal of Neuroradiology
|March 1, 1997
Summary
This study details a rare case of alobar holoprosencephaly with cyclopia in a neonate. Imaging revealed a single orbit with two globes, a shared optic nerve, and duplicated orbital structures.
Area of Science:
- Developmental biology
- Medical imaging
- Neurology
Background:
- Alobar holoprosencephaly is a severe congenital brain malformation.
- Facial anomalies, including cyclopia, are characteristic but rare presentations.
- Understanding the detailed anatomy is crucial for diagnosis and research.
Observation:
- A neonate with alobar holoprosencephaly presented with cyclopia and other malformations.
- Postmortem Magnetic Resonance (MR) and Computed Tomography (CT) imaging were performed.
- The examination focused on facial and intracranial structures.
Findings:
- A single midline orbit housed two globes, each with a distinct lens.
- A single optic nerve supplied both globes.
- Two separate superior orbital fissures and two distinct lateral rectus muscles were identified.
Implications:
- This case provides detailed anatomical insights into a severe holoprosencephaly variant.
- It highlights the complex variations in orbital and cranial nerve development.
- Such findings contribute to the understanding of forebrain development disorders.