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Related Experiment Videos

Stem cell transplantation: past, present and future

E D Thomas1

  • 1Fred Hutchinson Cancer Research Center, Seattle, WA 98104, USA.

Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1997
PubMed
Summary
This summary is machine-generated.

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Hematopoietic stem cell transplantation has evolved significantly, improving success rates for various diseases. Advances in donor matching, stem cell sources like peripheral blood and cord blood, and supportive therapies enhance patient outcomes and reduce costs.

Area of Science:

  • Hematology
  • Immunology
  • Oncology

Background:

  • Early human allogeneic marrow transplants (1950s-1960s) had low success rates.
  • Significant advancements in the last two decades have improved transplant outcomes.
  • Graft-versus-host disease and malignant cell elimination remain key challenges.

Purpose of the Study:

  • To review the evolution and current state of hematopoietic stem cell transplantation.
  • To highlight advancements in donor selection, stem cell sources, and supportive care.
  • To discuss the increasing use of autologous transplants and novel stem cell collection methods.

Main Methods:

  • Review of historical data and current research trends in marrow transplantation.
  • Analysis of cure rates for malignant and non-malignant diseases.

Related Experiment Videos

  • Examination of stem cell sources including sibling donors, unrelated donors, peripheral blood, and cord blood.

    • Main Results:

    • Cure rates vary widely, from 90% for early non-malignant diseases to 15% for advanced leukemia.
    • Matched unrelated volunteer donors are increasingly available.
    • Mobilization of hematopoietic stem cells from peripheral blood and use of cord blood are established practices.

    Conclusions:

    • Hematopoietic stem cell transplantation has become a more viable treatment option with improved success rates.
    • Ongoing research focuses on refining preparative regimens, preventing graft-versus-host disease, and utilizing growth factors.
    • Technological advances have reduced hospitalization time and costs associated with transplantation.