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Age-related normal uptake of 99mTc-MDP in the lower spine
G M Sundkvist1, B Lilja, S Mattsson
1Department of Clinical Physiology, Centralsjukhuset, Kristianstad, Sweden.
Aim:
The uptake of 99mTc-MDP in the lower spine was quantified in connection with ordinary bone scintigraphy.
Methods:
Fifty-seven women and seventy-two men (aged 20-69 y), with no signs of metabolic or malignant disease and no history of back pain or atraumatic fractures, were included in the study.
Results:
The women showed an increase in 99mTc-MDP uptake from the age of 20 y to about 45 y with a decrease from the time of menopause. In contrast to women, the uptake in men showed a slight decrease from the age of 20 y to about 50 y and thereafter a more marked decrease was seen. The major difference between men and women is the high premenopausal uptake in the female skeleton.
Conclusion:
An understanding of age-related changes in 99mTc-MDP uptake, which are indices of the skeletal metabolism, is of importance especially in prevention and treatment of osteoporosis, a common disorder in postmenopausal women.