Related Experiment Video
Updated: Aug 14, 2026

Use of Ultra-high Field MRI in Small Rodent Models of Polycystic Kidney Disease for In Vivo Phenotyping and Drug Monitoring
Published on: June 23, 2015
Chronic tubulo-interstitial nephropathy in children with cranioectodermal dysplasia
G A Savill1, I D Young, R J Cunningham
1Paediatric Renal Unit, Nottingham City Hospital, UK.
Cranioectodermal dysplasia (CED) is linked to chronic kidney disease, specifically tubulo-interstitial nephropathy. This rare syndrome poses a significant risk for renal failure in affected children, impacting long-term health.
Area of Science:
- Nephrology
- Genetics
- Pediatrics
Background:
- Cranioectodermal dysplasia (CED) is a rare genetic disorder.
- Previous literature has not documented renal involvement in CED.
Observation:
- Two pairs of siblings diagnosed with CED presented with chronic renal failure.
- The renal failure was attributed to tubulo-interstitial nephropathy.
Findings:
- Renal disease has now been observed in four out of seven reported CED cases.
- Children with CED demonstrate a significant risk for developing chronic renal failure.
Implications:
- This highlights a previously unrecognized complication of CED.
- Clinicians must consider long-term renal monitoring for children with CED.
- Early detection and management are crucial for improving the prognosis of renal disease in CED patients.
More Related Videos
08:46Implementing Patch Clamp and Live Fluorescence Microscopy to Monitor Functional Properties of Freshly Isolated PKD Epithelium
Published on: September 1, 2015
09:40Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells
Published on: June 20, 2018
Related Concept Videos
Continuous Renal Replacement Therapy
Kidney Transplant II: Surgical Procedure
Acute Kidney Injury II: Pathophysiology
Acute Kidney Injury III: Clinical Manifestations
Acute Kidney Injury IV: Diagnostic Studies and Prevention