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Advances in microbial steroid biotransformation

S B Mahato1, S Garai

  • 1Indian Institute of Chemical Biology, Calcutta, India.

Steroids
|April 1, 1997
PubMed
Summary
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This review highlights microbial biotransformations of steroids, focusing on hydroxylation and bond cleavage. It covers new microbial reactions and enzymatic catalysis advancements from 1992-1995.

Area of Science:

  • Biotechnology and Microbiology
  • Biocatalysis and Enzyme Engineering

Background:

  • Steroid biotransformations are crucial for synthesizing complex molecules.
  • Microbial methods offer environmentally friendly alternatives to chemical synthesis.
  • Advancements in microbial steroid modification have expanded synthetic possibilities.

Purpose of the Study:

  • To review microbial biotransformations of steroids from 1992-1995.
  • To highlight key developmental studies in steroid modification.
  • To compile microorganisms, substrates, and metabolites involved.

Main Methods:

  • Literature review of microbial biotransformations.
  • Focus on hydroxylation and carbon-carbon bond cleavage.
  • Exploration of enzymatic catalysis in nonaqueous solvents and cell immobilization.

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Main Results:

  • Compilation of various steroid substrates and their microbial metabolites.
  • Identification of microorganisms utilized for steroid transformations.
  • Overview of new microbial reactions and biotechnological approaches.

Conclusions:

  • Microbial biotransformations provide versatile routes for steroid modification.
  • Enzymatic catalysis and cell immobilization are key enabling technologies.
  • The reviewed period (1992-1995) showed significant progress in the field.