[Pleiotropic physiological effects of mutation di, which determines diabetes insipidus in rats]

The main phenotypic expression of mutation di is diabetes insipidus, which is pronounced in didi homozygotes. Additional physiological traits have been revealed that are associated with diabetes insipidus and are accounted for by the pleiotropic effect of gene di on the function of the reproductive system, metabolism of neurotransmitters in brain, and central regulation of the stress response. In didi mutants, the age-related decrease in fertility is retarded, the increase in B monoamine oxidase activity associated with aging is shifted to an older age, and the level of corticosteroid-binding globulin is decreased in young animals.