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[A study on midecamycin granules in acute respiratory diseases in infants (author's transl)]
Insights
Midecamycin granules show effective absorption and excretion in infants. This antibiotic demonstrated a 79% efficacy in treating acute infections like tonsillitis and bronchitis, with excellent results in Mycoplasma pneumonia cases.
Area of Science:
- Pharmacology
- Pediatric Infectious Diseases
Background:
- Midecamycin is a macrolide antibiotic.
- Basic and clinical studies are essential to evaluate new antibiotic formulations for pediatric use.
Abstract:
We have undertaken some basic and clinical studies on midecamycin granules with following results: 1) After ingesting of 4 g of midecamycin granules, peak blood levels (1.51 microgram/ml on an average) appeared at one hour in infants, detectable amount lasting for 6 hours. 2) Urinary excretion within 6 hours ranged from 1.1 to 2.7% of the drug dosed. 3) In the treatment of a total of 19 acute cases, consisting of 9 cases of tonsillitis, 7 cases of lacunar tonsillitis and 3 cases of bronchitis, midecamycin was found effective in 79% of the cases. 4) In all the 3 cases of pneumonia due to Mycoplasma, response to midecamycin was assessed as excellent. 5) Hepatic and renal functions tests performed in cases treated with the drug for a prolonged period (40 approximately 50 mg/kg for 13 approximately 18 days) revealed no undesirable effect, indicating that midecamycin can be administered continuously to younger infants with infections.