[Creatine phosphokinase activity in cerebrospinal fluid in purulent meningitis]

32 patients with purulent meningitis were examined. Depending on clinical course and CSF cytosis they were divided into three groups: 1-7 patients with mild course and cytosis, mean = 290.76/1 mm3; 2-15 patients with moderate course and cytosis mean = 2361.0/1 mm3; 3-10 patients with severe course and cytosis mean = 15466/1 mm3. Control group consisted of 28 patients without symptoms of meningitis. The investigation showed significant increase of CPK in CSF, the highest in group 3 which maintain after treatment despite normalization of CSF parameters. The presence of correlation between CPK activity and protein concentration (not with cytosis and glucose concentration) was stated. In serum of these patients CPK concentration was significantly higher in comparison with control. There was no correlation between CPK activity in CSF and serum. Indication between CPK in CSF among patients with purulent meningitis can be used in prognosis of the course of the disease and to estimate the efficacy of treatment.