[Etiopathogenesis of rheumatoid arthritis]

Rheumatoid arthritis is a disease, which etiopathogenesis depends on genetic and environment factors. Little is the progress of knowledge the environment factors but the strong is association with HLA DR4/DR1. The hypothesis being proposed is that RA is a chronic immune-mediated disease whose initiation and perpetuation is dependent on T-cell CD4 helper is connected by activation monocyte/macrophage cells which per production proteolytic enzymes and prostaglandins way to local inflammation and destruction articular cartilage and bone. Lymphocytes B proliferate to plasmocytes, which produce rheumatoid factor and other antibodies. Production of antibodies leads to production immune complexes, activation complement and migration and activation granulocytes. In the end of the process of RA occurs destruction articular cartilage and osteoclasts activated to erode bone together with mastocytes and growing pannus leads to synostosis. Like self perpetuation inflammation never disappears.